Propylthiouracil Is Teratogenic in Murine Embryos

Propylthiouracil Is Teratogenic in Murine Embryos

BACKGROUND Hyperthyroidism during pregnancy is treated with the antithyroid drugs (ATD) propylthiouracil (PTU) and methimazole (MMI). PTU currently is recommended as the drug of choice during early pregnancy. Yet, despite widespread ATD use in pregnancy, formal studies of ATD teratogenic effects have not been performed. METHODS We examined the teratogenic effects of PTU and MMI during embryog...

Teratogenic action of adenine on mouse embryos.

Several purine analogues are reported to show a teratogenic action in mammalian embryos when ad ministered at calculated dosage [reviewed by Giroud and Tuchmann-Duplessis-(1), Cahen (2) and Nishimura (3, 4); Kury et al. (5)]. We established that some methylated xanthines such as theophylline, theobromine and caffeine induce skeletal defects and subcutaneous hematoma in mice (6). Hypoxanthine al...

TERATOGENIC EFFECTS OF LITHIUM CARBONATE ON DEVELOPMENT OF MOUSE EMBRYOS

Teratogenic activity of methadone hydrochloride in mouse and chick embryos.

Teratogenic activity of methadone HC1 (Physeptone, Burroughs Wellcome and Co.) was tested on inbred JBT/Jd and outbred Q strain mouse embryos and on chick embryos. 22-24 mg/kg injected subcutaneously on the 9th day of pregnancy caused by the 13th day exencephaly in 56 out of 479 JBT/Jd embryos but after 32 mg/kg only in 1 out of 220 of the Q strain. Some affected JBT/Jd embryos showed also rach...

Teratogenic effects of pantothenic acid antagonists on animal embryos.

In 1946 Nelson and Evans (1) reported that pantothenic acid (PaA) deficiency in rats often resulted in the fetal death with resorption, and suggested the importance of vitamins in the development of embryos. Lefebvres-Boisselot (2) observed a high incidence of cerebral and ocular defects, digital hemor rhages and edema in the fetuses from PaA-deficient rats. In 1948 Ackermann and Taylor (3) fir...